| Autor: | Ángel Sánchez-Rodríguez, Alejandro Esteller, Olga Flores, Manuela Criado, J. A. Martín-Oterino, A. Olveira-Martín |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Creatinine Cirrhosis integumentary system biology Physiology business.industry medicine.medical_treatment Gastroenterology Albumin medicine.disease carbohydrates (lipids) Glycosaminoglycan chemistry.chemical_compound Endocrinology Cytokine chemistry Internal medicine Ascites Hyaluronic acid medicine biology.protein medicine.symptom business Interleukin 6 |
| Zdroj: | Digestive Diseases and Sciences. 45:2229-2232 |
| ISSN: | 0163-2116 |
| Popis: | Our objective was to investigate the relationship between endotoxin and hyaluronan synthesis and release in serum and ascitic fluid from cirrhotic patients. We studied hyaluronan, endotoxin, albumin, and creatinine levels in ascitic fluid and plasma and cytokine levels (IL-1β, IL-6, TGF-β) in ascitic fluid. TGF-β, IL-6, and IL-1β correlation analyses indicated a strong dependence of the production of these cytokines on endotoxin levels. Correlation analyses for TGF-β and IL-6 indicated a strong dependence of the production of hyaluronan on cytokine levels and, to a lesser extent, on IL-1β levels. Hyaluronan analysis indicated that a certain glycosaminoglycan level is required in ascites before its appearance in plasma. Our results disclosed elevated plasma hyaluronan concentrations. The simultaneous increased hyaluronan levels in ascitic fluid do not seem to be derived from the systemic circulation. In conclusion, the high hyaluronan-ascites/hyaluronan-plasma ratio suggests an intrinsic hyaluronan production from peritoneal cells induced by endotoxins. |
| Databáze: | OpenAIRE |
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