Risk factors and prognostic significance of altered left ventricular geometry in preterm infants
| Autor: | Tyler W. Cunningham, Mark C. Johnson, Swati Choudhry, Brian P. Hackett, Philip T. Levy, Gautam K. Singh, Amber Salter |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Obstetrics and Gynecology Retrospective cohort study 030204 cardiovascular system & hematology medicine.disease Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Predictive value of tests Internal medicine Pediatrics Perinatology and Child Health Cohort medicine Cardiology Small for gestational age Left ventricular geometry Risk assessment Wall thickness business |
| Zdroj: | Journal of Perinatology. 38:543-549 |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | Left ventricular (LV) hypertrophy (LVH) predicts adverse cardiac events in adults. We sought to determine the risk factors and prognostic significance of altered LV geometry in preterm infants. In an echocardiographic, single-center, retrospective case–control study we investigated the risk factors and outcomes in patients with altered LV geometry (either increased left ventricular mass index (LVMI) or increased relative wall thickness (RWT)) from a cohort of 503 preterm infants ≤2 kg. Altered LV geometry was seen in 180 patients and was predicted by postnatal steroids and small for gestational age. Hospital stay was longer in the elevated RWT cases. Altered LV geometry resolved in 129 of the 131 cases with follow-up echocardiogram. Fifteen of 94 patients with elevated RWT died compared to 3/90 controls (P = 0.004). Altered LV geometry in preterm infants is associated with postnatal steroid use and small for gestational age. Elevated RWT is associated with longer hospital stay and increased mortality. |
| Databáze: | OpenAIRE |
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