Highly efficient microwave-assisted one-pot synthesis of 4-aryl-2-aminothiazoles in aqueous medium
| Autor: | Devendra S. Wagare, Mazahar Farooqui, Mujahed Shaikh, Ayesha Durrani, Prashant D. Netankar |
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| Rok vydání: | 2017 |
| Předmět: |
Aryl
One-pot synthesis 02 engineering and technology Polyethylene glycol 010501 environmental sciences 021001 nanoscience & nanotechnology 01 natural sciences Solvent chemistry.chemical_compound chemistry Yield (chemistry) PEG ratio Environmental Chemistry Organic chemistry N-Bromosuccinimide 0210 nano-technology Thiazole 0105 earth and related environmental sciences |
| Zdroj: | Environmental Chemistry Letters. 15:475-479 |
| ISSN: | 1610-3661 1610-3653 |
| Popis: | The thiazole ring system is one of the most important heterocycles in nature, as it represents an important structural motif of many biological compounds, including vitamin B1 (Thiamin), carboxylase and penicillin. There is, therefore, an urgent need to design rapid, efficient and environmentally benign protocols for the synthesis of thiazoles. Herein, we have developed a one-pot protocol for the synthesis of 4-aryl-2-aminothiazoles from the reaction of aromatic ketones, NBS (N-Bromosuccinimide) and thioureas under microwave irradiation at 80–85 °C in PEG (polyethylene glycol)-400 and water as a green reaction medium. The products were obtained in 84–89% yields in 28–32 min. The method has several advantages such as use of green solvent, easy work-up, excellent yield and avoiding use of lachrymatric α-haloketones. |
| Databáze: | OpenAIRE |
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