Primary central nervous system germ cell tumors. Effect of histologic confirmation on radiotherapy
| Autor: | Donald R. Eisert, Richard D. Marks, Seung S. Hahn, C. Ronald Kersh, Cynthia A. Spaulding, William C. Constable, Joseph M. Jenrette |
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| Rok vydání: | 1988 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty education.field_of_study Germinoma medicine.diagnostic_test business.industry medicine.medical_treatment Population medicine.disease Malignancy Craniospinal Irradiation Radiation therapy Oncology Biopsy medicine Germ cell tumors education business Survival rate |
| Zdroj: | Cancer. 61:2148-2152 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19880601)61:11<2148::aid-cncr2820611103>3.0.co;2-q |
| Popis: | Primary malignant intracranial germ cell tumors are rare lesions responsible for only 0.5% of all central nervous system (CNS) malignancy. With stereotactic localization these lesions can be safely biopsied, and histologic confirmation will affect the ultimate prognosis. This report is a multi-institutional retrospective analysis of 33 patients diagnosed with a primary CNS germ cell tumor. Tumors in 14 patients (42%) were histologically confirmed (13 germinoma and one embryonal cell carcinoma); 19 patients were treated with a presumptive diagnosis. All patients were irradiated with a dose range of 3950 cGy to 6000 cGy to the primary lesions. Eight patients received craniospinal irradiation, and 25 patients were locally treated. The 5-year actuarial survival for the entire population was 64%. The survival rate in patients with histologic confirmation was 79% versus 53% in the unbiopsied population. Radiation doses greater than 5000 cGy, radiotherapy volume, and age were prognostic factors in determining survival. |
| Databáze: | OpenAIRE |
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