Chiral resolution of some antimalarial agents by sub- and supercritical fluid chromatography on an (S)-naphthylurea stationary phase

Autor:	Irving W. Wainer, Arlette Baillet, Gilles Peytavin, Robert Farinotti, C. Gillotin, Françlois Gimenez, Brigitte Genissel
Rok vydání:	1993
Předmět:	Pharmacology Quinidine Chromatography Mefloquine Organic Chemistry Catalysis Chiral resolution Analytical Chemistry chemistry.chemical_compound chemistry Halofantrine Drug Discovery Supercritical fluid chromatography medicine Methanol Enantiomer Triethylamine Spectroscopy medicine.drug
Zdroj:	Chirality. 5:173-180
ISSN:	1520-636X 0899-0042
DOI:	10.1002/chir.530050313
Popis:	The behavior of mefloquine, halofantrine, enpiroline, quinine, quinidine, chloroquine and primaquine is studied by subcritical fluid chromatography on a (S)-naphthylurea column (250 mm × 4.6 mm ID) with a subcritical mobile phase composed of carbon dioxide, methanol and triethylamine (flow rate of 3 ml/min). Except for primaquine and chloroquine, each enantiomer was separated at a temperature between 40 and 60°C, and at a pressure below 15 MPa. A 98/2, v/v CO2/methanol 0.1% triethylamine mixture allowed the separation of halofantrine enantiomers while the enantiomers of the more polar metabolite (N-desbutylhalofantrine) were separated with a 80–20 v/v mixture as used for mefloquine, enpiroline, quinine and quinidine. The influence of temperature, pressure and of the nature of the mobile phase is discussed. © 1993 Wiley-Liss, Inc.
Databáze:	OpenAIRE
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