Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor

Autor:	M. V. Larina, N. A. Lyzhko, L. A. Kesaeva, T. K. Aliev, NN Kasatkina, V. A. Misyurin, Mikhail P. Kirpichnikov, A. V. Misyurin, O. N. Solopova, A. A. Turba, Yu. P. Finashutina
Rok vydání:	2021
Předmět:	0303 health sciences PRAME biology medicine.drug_class 030302 biochemistry & molecular biology Biophysics General Chemistry General Medicine Monoclonal antibody Biochemistry PRAME Gene Epitope 03 medical and health sciences medicine biology.protein Cancer research Cancer/testis antigens Tumor growth Vector (molecular biology) Antibody 030304 developmental biology
Zdroj:	Doklady Biochemistry and Biophysics. 498:199-202
ISSN:	1608-3091 1607-6729
Popis:	Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1cf122ed562a8a5d3569ab71e94a96a6 https://doi.org/10.1134/s1607672921030091 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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