Facile One-pot, Three-component Synthesis of Novel Bis-heterocycles Incorporating 5H-chromeno[2,3-b]pyridine-3-carbonitrile Derivatives

Autor:	Said A. S. Ghozlan, Ahmed H. M. Elwahy, Ismail A. Abdelhamid, Doaa M. Abdelmoniem, Amr M. Abdelmoniem
Rok vydání:	2017
Předmět:	010405 organic chemistry Dimer Organic Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Dimedone Pyridine Piperidine Spectral data Malononitrile
Zdroj:	Journal of Heterocyclic Chemistry. 54:2844-2849
ISSN:	0022-152X
DOI:	10.1002/jhet.2890
Popis:	Novel bis-chromeno[2,3-b]pyridine derivatives were synthesized with good yields by a clean and efficient methodologies involving one-pot three-component synthesis of bis-aldehydes, malononitrile dimer, and dimedone in the presence of piperidine as a catalyst in EtOH. Depending on the length and position of the spacer in the bis-aldehyde derivatives 1, the reactions proceeded to give either the bis(2,4-diamino-tetrahydro-5H-chromeno[2,3-b]pyridine-3-carbonitriles) 4 or bis(4-amino-2,6-dioxo-hexahydro-2H-chromeno[2,3-b]pyridine-3-carbonitriles) 5. All of the new compounds have been characterized by spectral data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1cee60381a8856f7dd9821468bd74176 https://doi.org/10.1002/jhet.2890 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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