Visible light-cured glycol chitosan hydrogel dressing containing endothelial growth factor and basic fibroblast growth factor accelerates wound healing in vivo
| Autor: | Sun-Jung Yoon, Sewook Um, Deok-Won Lee, So Yeon Kim, Young-Bum Yoo, Sung Ok Hong, Hoon Hyun, Dae Hyeok Yang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell growth General Chemical Engineering Growth factor medicine.medical_treatment Basic fibroblast growth factor 02 engineering and technology 021001 nanoscience & nanotechnology Fibroblast growth factor Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry In vivo Cell culture Self-healing hydrogels medicine 0210 nano-technology Wound healing |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 67:365-372 |
| ISSN: | 1226-086X |
| Popis: | Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF and GCH-EGF/FGF) and evaluated their efficacies on the improvement of wound healing in vivo. In vitro release test showed that the growth factors were released in a sustained manner along with initial burst for 24 h. In vitro cell proliferation assay of L-929 mouse fibroblast cell line resulted in the superior ability of GCH-EGF/FGF on the rate. In vivo results demonstrated that the growth factor loaded GCHs further enhanced wound healing compared with GCH. In particular, GCH-EGF/EFG showed the most remarkable wound healing effect among the samples. |
| Databáze: | OpenAIRE |
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