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Publisher Summary In recent years there has been a great increase in interest in hypervitaminosis A, the intoxication resulting from an excess intake of vitamin A. Hypervitaminosis A in experimental animals, which was first studied and which has also been the best studied, gives a closer insight into the biochemical behavior of large quantities of vitamin A, in particular with regard to its interaction with other nutrients in vivo. The disturbance of the physiologic equilibrium between vitamin A and other factors, caused by the hypervitaminosis, makes possible a fresh approach to information concerning the normal function of vitamin A in the body. In this respect the effects of experimental hypervitaminosis A provide another starting point for fundamental research into the biochemistry of vitamin A. Data on hypervitaminosis A in man have become available more recently, and can be obtained clinically only when very large doses of vitamin A are ingested. As a result this intoxication is very seldom seen in practice. However, it must be remembered that subclinical toxicity because of large amounts of vitamin A such as are used therapeutically in medical practice in various diseases might be possible. It is useful in this respect also to have data derived from experiments with animals. |
