SARS-COV-2: A Current Update About Miscellaneous Symptoms

Autor: Tuba Tülay KOCA, Saime SAĞIROĞLU
Rok vydání: 2021
Předmět:
Zdroj: Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi. 24:294-298
ISSN: 1307-7384
1309-3843
DOI: 10.31609/jpmrs.2021-82578
Popis: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) particle causes different clinical responses in the host depending on the genetic background and prolonged symptoms may develop after recovery. With today's knowledge, we may describe SARS-CoV-2 infection the cause of an autoimmune viral vasculopathy clinic. With our current information, it is not clear which patients will develop severe or prolonged disease. There are many different pathophysiological mechanisms that cause coronavirus disease-2019-related symptoms like chronic pain, fatigue, sarcopenia, vasculopathy, autoimmun disorders, arthritis and central sensitization etc.We now know that SARS-CoV-2 causes immune response and life-threatening conditions as a result of microthrombosis and endothelial dysfunction in many vital organs. Also it triggers an immune response in the host. This immun reaction may trigger autoimmune diseases in the long term. In this review, we especially focused on miscellaneous symptoms caused by virus, from the perspective of a physiatrist, besides systemic complications. Siddetli akut solunum sendromu-koronavirus-2 [severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)] partikulu, genetik zemine bagli olarak konakta farkli klinik yanitlara neden olur ve iyilesmeden sonra uzun sureli semptomlar gelisebilir. Gunumuzun bilgisiyle, SARS-CoV-2 enfeksiyonunu bir otoimmun viral vaskulopati kliniginin nedeni olarak tanimlayabiliriz. Mevcut bilgilerimizle hangi hastalarin siddetli veya uzun sureli hastalik gelistirecegi net degildir. Kronik agri, yorgunluk, sarkopeni, vaskulopati, otoimmun bozukluklar, artrit ve santral sensitizasyon gibi SARS-CoV-2 ile iliskili semptomlara neden olan bircok farkli patofizyolojik mekanizma vardir. SARS-CoV- 2'nin bircok hayati organda mikrotromboz ve endotel disfonksiyonunun sonucu immun yanit ve yasami tehdit eden durumlara neden oldugunu artik biliyoruz. Ayrica konakta bir immun yaniti tetikler. Bu immun reaksiyon, uzun vadede otoimmun hastaliklari tetikleyebilir. Bu derlemede, sistemik komplikasyonlarin yani sira ozellikle bir fiziyatrist bakis acisindan virusun neden oldugu cesitli semptomlara odaklandik.
Databáze: OpenAIRE
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