Antidiabetic potential of Rourea minor (Gaertn.) root in streptozotocin—induced diabetic rats

Autor: Sonam Shukla, Ankur R. Patel, Preeti V Kulkarni, Vishal J Patel, Venkatrao H. Kulkarni
Rok vydání: 2013
Předmět:
Zdroj: Oriental Pharmacy and Experimental Medicine. 14:69-76
ISSN: 2211-1069
1598-2386
DOI: 10.1007/s13596-013-0129-z
Popis: The present investigation aims to examine the antihyperglycemic potential of Rourea minor (Gaertn.) root in normal and streptozotocin (STZ) induced diabetic rats. The root of Rourea minor (Gaertn.) was extracted using ethanol and water and tested for acute toxicity by up and down staircase method. The aqueous Rourea minor (Gaertn.) water (RMW) extract and ethanolic Rourea minor (Gaertn.) extract (RME) at 200 and 400 mg/kg bodyweight doses were screened for blood glucose lowering capacity in normal and STZ induced diabetic animals; the blood samples were collected from the retro orbital plexus and analyzed for serum glucose (SG) level. Glibenclamide (GLB) was used as a standard. The oral glucose tolerance test (OGTT) was carried out in normal as well as STZ induced diabetic rats whereas, insulin tolerance test was carried out in diabetic rats. At the end of 15 days treatment, serum triglyceride (STG), total cholesterol (STC) and HDL-cholesterol (HDL-c) were assayed by auto analyzer. The results of acute toxicity showed that the animals had good tolerance to single doses of RME/RMW (as high as 3 g/kg) and were non-lethal. The glucose tolerance test in normal rats showed that treatment of RME, RMW (both 400 mg/kg), RME (200 mg/kg) and GLB (0.5 mg/kg) exhibited significant reduction (p
Databáze: OpenAIRE
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