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Hypertension impairs the cerebral vasculature resulting in vascular cognitive impairment [VCI]. The role of obesity and plasma lipids shown as risk factors in development of VCI in adults with hypertension is unclear and is investigated in this study. Normoglycemic individuals [n=216] aged 40-75 years were enrolled into this study between January and December 2019. They included Newly Diagnosed Hypertensives with [NDHCI, n-69] and without Cognitive Impairment [NDH, n-81], age-matched with 66 apparently healthy individuals [Controls]. Anthropometric measures [height, weight, waist circumference [WC], Hip circumference [HC], waist hip rratio [WHR] and body mass index [BMI] and socio-demographic indices, lifestyle and blood pressure were obtained using standard methods. Plasma lipids [Total cholesterol [TC], high density lipoprotein cholesterol [HDL-C], Triglyceride [TG] were determined spectrophotometrically, while low density lipoprotein cholesterol [LDL-C] was calculated using Friedewald formula. Neuropsychological assessment based on cognitive score [CS] was done using community screening instrument for dementia [CSID]. Data were analyzed using statistical package for social sciences [SPSS] software 17.0 version. Analysis of variance [ANOVA] and Post Hoc test were used for comparison of variables while Chi square test was used to find associations between variables. These were considered significant at p |
