Influence of N,N′-Substituted Piperazines on Cytolysis
| Autor: | N. N. Petrishchev, M. E. Borovitov, L. V. Galebskaya, E. A. Vorob’ev, D. I. Nilov, I. L. Solovtsova, O. S. Veselkina, K. S. Len’shina, M. A. Solov’eva |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology Antioxidant Lysis 030111 toxicology medicine.medical_treatment medicine.disease Medicinal chemistry Hemolytic Process Hemolysis Complement system 03 medical and health sciences Cytolysis Piperazine chemistry.chemical_compound 030104 developmental biology Biochemistry chemistry Drug Discovery medicine Photosensitizer |
| Zdroj: | Pharmaceutical Chemistry Journal. 49:743-748 |
| ISSN: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-016-1363-8 |
| Popis: | The hemolytic activity of N,N′-substituted piperazines and their influence on the hemolytic process initiated by radiation (red LED, 653 nm) in the presence of radachlorin (RADA-FARMA, Russia) photosensitizer and on complement-dependent hemolysis were studied. All compounds did not cause human RBC lysis in the studied concentration range (0.15 – 3.0 mM) although dose-dependent inhibition of photo-induced hemolysis that manifested as an increase of the 50% lysis time was observed. The piperazine derivatives did not substantially influence RBC lysis by the activated complement. Therefore, the antihemolytic effect of the N,N’-substituted piperazines was due to their antioxidant activity. |
| Databáze: | OpenAIRE |
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