Effects of folate, vitamin B-12 and vitamin B-6 supplementation on methionine-induced hyperhomocysteinemia in rats
| Autor: | G. Sarwar Gilani, H.G. Botting, Robert W. Peace |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Vitamin
medicine.medical_specialty Hyperhomocysteinemia Nutrition and Dietetics Methionine Homocysteine business.industry Endocrinology Diabetes and Metabolism Micronutrient medicine.disease Pyridoxine chemistry.chemical_compound B vitamins Endocrinology chemistry Internal medicine medicine Cyanocobalamin business medicine.drug |
| Zdroj: | Nutrition Research. 21:1501-1507 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(01)00389-x |
| Popis: | An excessive intake of dietary methionine increases plasma total homocysteine (tHcy, an independent risk factor for premature cardiovascular disease) by enhancing the synthesis of homocysteine. Information on the influence of excess dietary vitamins involved in homocysteine metabolism on the methionine-induced hyperhomocysteinemia is, however, limited. Thus, a six-week study was conducted to determine the influence of excess folic acid, vitamin B-12 and vitamin B-6 on the methionine-induced hyperhomocysteinemia in rats. Supplementation of the casein control diet with 10 and 20 g/kg L-Met increased plasma tHcy to 2.0 and 8.0 times control, respectively. The hyperhomocysteinemia caused by the addition of 10 g/kg L-Met to the control diet, was completely counteracted by extra folic acid or three vitamins combined (folic acid, 2 mg/kg; vitamin B-12, 25 μg/kg; plus vitamin B-6, 6 mg/kg) but the addition of extra vitamin B-12 or vitamin B-6 alone had no effect on plasma tHcy. Similarly, extra dietary folic acid or the three vitamins combined caused substantial reduction in plasma tHcy of rats fed the control diet supplemented with 20 g/kg L-Met but addition of vitamin B-12 or vitamin B-6 alone exacerbated plasma tHcy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect