Untersuchungen zur Nierenfunktion nierengesunder Patienten unter Ciclosporin
| Autor: | T. Reinhard, Peter Heering, G. Kreuzpaintner, B. Kutkuhn, Bernd Grabensee, R. Sundmacher |
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| Rok vydání: | 1991 |
| Předmět: |
Inulin Clearance
Creatinine medicine.medical_specialty business.industry Urology Renal function Furosemide General Medicine PAH clearance Ciclosporin Plasma renin activity Nephrotoxicity chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine business Genetics (clinical) medicine.drug |
| Zdroj: | Klinische Wochenschrift. 69:880-886 |
| ISSN: | 1432-1440 0023-2173 |
| Popis: | Long-term administration of ciclosporin has been complicated by side-effects, the predominant being nephrotoxicity. We performed renal function studies on 20 patients treated with ciclosporin (group 1) and on 12 patients serving as controls (group 2). Only patients with serum creatinine less than 1.3 mg/dl entered the study. The renal function studies consisted of: Inulin clearance, PAH clearance, sodium sulphate loading, sodium bicarbonate loading. Plasma renin activity (PRA), inactive renin (IR) and aldosterone (ALDO) were measured basally and after stimulation with 40 mg furosemide i.v. Serum creatinine was not significantly impaired under ciclosporin with 1.1±0.1 mg/dl vs 0.9±0.1 mg/dl in the control group (ns). Glomerular filtration rates as measured by creatinine and inulin clearance were significantly impaired in group 1 as compared to group 2. Inulin clearance was impaired by ciclosporin with 93.5±4.4 ml/min/1.73m2 as compared to 121±6.6 ml/min/1.73 m2 (p |
| Databáze: | OpenAIRE |
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