An efficient synthesis and biological study of substituted 8-chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines, their sulphones and ribofuranosides

Autor:	Naveen Gautam, Abhilasha, Nishidha Khandelwal, Dinesh Chand Gautam
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Acetic acid chemistry.chemical_compound Base (chemistry) Chemistry Organic chemistry General Chemistry Hydrogen peroxide Antimicrobial
Zdroj:	Journal of Chemical Sciences. 125:85-93
ISSN:	0973-7103 0974-3626
DOI:	10.1007/s12039-013-0363-4
Popis:	8-Chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines were synthesized by condensation followed by oxidative cyclisation of 2-amino-6-chloro-3-methoxy/2-amino-3-chlorobenzenethiol with β–diketones/β–ketoesters in the presence of dimethyl sulphoxide. By treating 4H-1,4-benzothiazines with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazine-1,1-dioxides (sulphones) were synthesized. The 4H-1,4-benzothiazines have also been used as a base to prepare ribofuranosides by the reaction with β–D-ribofuranose-1-acetate-2,3,5-tribenzoate. All the synthesized compounds have been characterized by spectral and elemental analysis and have been examined for antimicrobial and anthelmintic activity.
Databáze:	OpenAIRE
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