Promoter polymorphism (T-1486C) of TLR-9 gene is associated with knee osteoarthritis in a Turkish population
| Autor: | Murat Korkmaz, Seda Sabah Ozcan, Ozlem Balbaloglu, Neziha Yilmaz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Turkish population business.industry Case-control study Single-nucleotide polymorphism Osteoarthritis medicine.disease 03 medical and health sciences 030104 developmental biology Polymorphism (computer science) Internal medicine Genotype Medicine SNP Orthopedics and Sports Medicine Gene polymorphism business |
| Zdroj: | Journal of Orthopaedic Research. 35:2484-2489 |
| ISSN: | 0736-0266 |
| DOI: | 10.1002/jor.23559 |
| Popis: | In this study, we aimed to determine whether TLR-9 T-1486C SNP was associated with susceptibility to OA in the Turkish population. The study group comprised 272 patients with Grade 2-3-4 knee OA according to the Kellgren-Lawrence scoring system and the control group was formed of 296 individuals with Grade 0-1. The TLR-9 genotype were assessed by real-time polymerase chain reaction. An analysis of TLR-9 promoter -1486T/C polymorphism revealed that the -1486CC genotype appeared to have a higher risk for OA and -1486TT and -1486CT genotypes have a protective effect against the development of OA (crude OR = 0.473, 95% CI = 0.297-0.754, p = 0.002, adjusted OR = 0.531, 95% CI = 0.326-0.864, p = 0.011). This study indicate that there is a correlation of TLR-9 T-1486C gene polymorphism with advanced knee OA in a Turkish population. Changed in TLR expression due to different allelles may cause osteoarthrith development outcome cartilage degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2484-2489, 2017. |
| Databáze: | OpenAIRE |
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