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In Haloferax volcanii, DNA replication is not arrested in the absence of protein synthesis. This DNA replication occurs either in complete medium during the inhibition of protein synthesis by anisomycin or in minimal medium during amino acid starvation of an auxotrophic mutant his-1. Once established, this DNA synthesis is permanent. It is also sensitive to aphidicolin, an inhibitor of eukaryotic chromosomal DNA replication. The entire chromosome seems to participate in this replication whereas the synthesis of the resident pHV2 plasmid is reversibly inhibited. |
