Monitoring the On-line Titration of Enantiomeric Omeprazole Employing Continuous-flow Capillary Microcoil 1 H NMR Spectroscopy

Autor:	Karsten Holtin, Lisa Steinhauser, Petra Hentschel, Klaus Albert
Rok vydání:	2012
Předmět:	Pharmacology Benzimidazole Dimer Chemical shift Organic Chemistry Analytical chemistry Nuclear magnetic resonance spectroscopy Microcoil Catalysis Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Proton NMR Titration Spectroscopy Nuclear chemistry
Zdroj:	Chirality. 24:1074-1076
ISSN:	0899-0042
DOI:	10.1002/chir.22099
Popis:	The titration of the (S)-enantiomer of omeprazole with the (R)-enantiomer in chloroform-d(1) is monitored by continuous-flow capillary microcoil (1)H NMR spectroscopy employing a microcoil with a detection volume of 1.5 µl. The observed changes of the (1)H NMR chemical shifts indicate the formation of a heterochiral (R,S) dimer of omeprazole via its sulfinyl group and the NH group of the benzimidazole ring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1cb892e4d97d9aa8eff510d60b440ddf https://doi.org/10.1002/chir.22099 Zobrazit plný text záznamu Plný text ve formátu PDF