Experimental Instradiscal Drug Injection: Histological Studies and Measurement of Intradiscal Pressure

Autor:	Teruyuki Hirohashi, Kazumasa Ishibashi, Kimiaki Sato, Akio Inoue, Masakazu Morita, Kensei Nagata, Teruaki Ohashi, Jun Abe
Rok vydání:	1996
Předmět:	medicine.medical_specialty biology business.industry Sodium Sodium Chloride Injection chemistry.chemical_element Chymopapain Surgery chemistry Anesthesia Disc degeneration medicine biology.protein Betamethasone business Intradiscal pressure medicine.drug
Zdroj:	Orthopedics & Traumatology. 45:123-126
ISSN:	1349-4333 0037-1033
Popis:	We investigated the pathological changes and alterations in intradiscal pressure after an experimental intradiscal injection in the mature rabbit. Thirty intervertebral discs in 6 rabbits were used as controls, and normal pressures were measured. Chymopapain, 10% sodium chloride, or betamethasone were injected separately into 5 intervertebral discs of 9 rabbits. Rabbits were sacrificed at 1 week, 4 weeks, and at 12 weeks after the intradiscal drug injection. The intradiscal pressure changed depending on the degree of disc degeneration and if there was any regeneration. The chymopapain-injected intradiscal pressure decreased significantly at 4 weeks compared with the pressure at 1 week and at 12 weeks (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1cb2cf43dea8da2e9bfc0105efab70ab https://doi.org/10.5035/nishiseisai.45.123 Zobrazit plný text záznamu