| Autor: |
Pérez Bastidas Me, Espinosa Morales R |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Reumatología Clínica. 3:S39-S43 |
| ISSN: |
1699-258X |
| DOI: |
10.1016/s1699-258x(07)73653-7 |
| Popis: |
The osteoarthritis is a disease with high epidemiological, social, and economic impact in health systems. Its treatment has been focused on diminishing pain and inflammation joint; in last years there has appeared on the market a series of drugs that, in studies in vitro show mechanisms of action that might have a modifying effect of disease, since they diminish the proinflammatory cytokines and metalloproteinases involved in degradation of cartilage matrix and it have effect in anti-apoptotics mechanisms in chondrocyte. Clinical studies have showed efficacy against pain and improving joint function; some studies have showed that there is not loss of joint space evaluated by conventional x-ray with longitudinal follow-up of patients. We describe new in vitro action mechanisms of theses new drugs and the clinical evidence of its efficacy in symptoms and potentially modifying effect of the natural history of osteoarthritis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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