Combination chemotherapy with cis-diamminedichloroplatinum, oncovin, and bleomycin (COB) in advanced head and neck cancer phase II
| Autor: | Magid H. Amer, Vainutis K. Vaitkevicius, Izbicki Rm, Muhyi Al-Sarraf |
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| Rok vydání: | 1980 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Vincristine business.industry Head and neck cancer Combination chemotherapy medicine.disease Bleomycin Gastroenterology Nephrotoxicity chemistry.chemical_compound Epidermoid carcinoma chemistry Internal medicine Toxicity medicine Cis-Diamminedichloroplatinum business medicine.drug |
| Zdroj: | Cancer. 45:217-223 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19800115)45:2<217::aid-cncr2820450204>3.0.co;2-8 |
| Popis: | Twenty-eight consecutive patients with advanced head and neck epidermoid carcinoma were treated with a single course of combination chemotherapy which included high dose cis-platinum II, vincristine, and bleomycin. All patients except one were evaluable for drug response and toxicity. The overall toxicity was mild and tolerable except in one patient who had fatal nephrotoxicity. Thirteen patients (48%) had a partial regression, and five with minimal response did improve, giving an overall response rate of 67%. More responses were noted in previously untreated patients, especially those with oral or hypopharyngeal tumors without distant metastases. Definite histological changes were seen in a few patients in remission. Objective tumor response was associated with subjective improvement, and, possibly, a prolonged survival. |
| Databáze: | OpenAIRE |
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