Core–shell nanogel of PEG–poly(aspartic acid) and its pH-responsive release of rh-insulin

Autor:	Jd Kim Jong-Duk Kim, Hj Lee Hyun-Jin Lee, Cw Park Chan-Woo Park, Hm Yang Hee-Man Yang
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Chemistry General Chemistry Polymer Condensed Matter Physics Micelle chemistry.chemical_compound Hydrolysis PEG ratio Polymer chemistry Aspartic acid medicine Swelling medicine.symptom Ethylene glycol Nanogel
Zdroj:	Soft Matter. 9:1781-1788
ISSN:	1744-6848 1744-683X
Popis:	A new synthesis approach for the preparation of pH-responsive nanogels via core hydrolysis of cross-linked polymer micelles is proposed. The core–shell nanogels of poly(ethylene glycol)–poly(aspartic acid) exhibited a pH-responsive swelling behavior attributed to the ionization of aspartic acids, and the swelling of the nanogels depended on the cross-linking density. Small-angle neutron scattering (SANS) data were used to investigate the structure and swelling behavior of the nanogels via fitting analysis based on a new model equation that describes two distinguishable scattering intensities that arise from the particle structure and the fluctuation of polymer networks. We estimated that the nanogel core can absorb a volume of water molecules up to 30 times the volume of the polymer itself. The hydrophilic nanogels were able to entrap a proteindrug, rh-insulin, and the drug release was retarded under acidic conditions due to deswelling of the nanogels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c9e1f9c3f732b69411f5f20c0296b1b https://doi.org/10.1039/c2sm26865e Zobrazit plný text záznamu