New spirocyclic sesquiterpenes from the marine sponge Geodia exigua

Autor:	Susumu Ikegami, Emi Ohta, Mihoko Yanai, Mylene M. Uy, Shinji Ohta, Toshifumi Hirata
Rok vydání:	2003
Předmět:	biology Stereochemistry Organic Chemistry Absolute configuration biology.organism_classification Biochemistry Decene chemistry.chemical_compound Sponge chemistry biology.animal Drug Discovery Exigua Geodia Amine gas treating Sea urchin Derivative (chemistry)
Zdroj:	Tetrahedron. 59:731-736
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(02)01619-8
Popis:	Three new spirocyclic sesquiterpenes designated exiguamide ( 1 ), exicarbamate ( 2 ) and exigurin ( 3 ), together with (−)-10- epi -axisonitrile-3 ( 4 ), have been isolated from the marine sponge Geodia exigua . All four compounds possess the spiro[4.5]decene skeleton and their structures were determined on the basis of spectroscopic data. The structure of 1 was confirmed by X-ray crystallographic analysis and the absolute configuration was determined by applying the modified Mosher's method on its amine derivative. Exiguamide ( 1 ) inhibited cell fate specification during sea urchin embryogenesis at a minimum inhibitory concentration of 0.4 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c9cc2788078069a719f4204dbd5f5c3 https://doi.org/10.1016/s0040-4020(02)01619-8 Zobrazit plný text záznamu Full Text from ScienceDirect