Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1

Autor:	Thomas Perrotton, Laurent Nault, Antoine Leydier, Celine Girardot, Anthony W. Coleman, Sandrine Magnard, Hélène Baubichon-Cortay
Rok vydání:	2010
Předmět:	Multiple drug resistance chemistry Dependent manner Magnesium Stereochemistry Cyclic nucleotide-binding domain Materials Chemistry chemistry.chemical_element Substrate (chemistry) MRP1 Protein General Chemistry Catalysis Fluorescence spectroscopy
Zdroj:	New Journal of Chemistry. 34:1812
ISSN:	1369-9261 1144-0546
Popis:	The tri-carboxylatomethylene-mono-alkoxy calix[4]arenes have been shown by fluorescence spectroscopy to bind to the NBD1 domain of MRP1 protein in a magnesium dependent manner. The observed associations constants are of the same order as that observed for ATP–Mg, the natural substrate for this protein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c9c34d8edff0efb8d7b16a5cc14dddf https://doi.org/10.1039/c0nj00323a Zobrazit plný text záznamu