Novel antifungal janthinopolyenemycins A and B from a co-culture of marine-associated Janthinobacterium spp. ZZ145 and ZZ148
| Autor: | Sidra Kaleem, Xiao-Yuan Lian, Zhizhen Zhang, Lei Chen, Xing-Cong Li, Izhar Sadiq, Komal Anjum |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Antifungal
biology 010405 organic chemistry Chemistry medicine.drug_class Chemical structure Organic Chemistry biology.organism_classification 01 natural sciences Biochemistry In vitro 0104 chemical sciences Microbiology Aquatic organisms 010404 medicinal & biomolecular chemistry Drug Discovery Janthinobacterium medicine Spectral data Candida albicans Bacteria |
| Zdroj: | Tetrahedron Letters. 59:3490-3494 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2018.08.022 |
| Popis: | Two rare polyketides, named as janthinopolyenemycins A (1) and B (2), were isolated from a co-culture of two marine-sourced bacteria Janthinobacterium spp. ZZ145 and ZZ148. Their structures were established by a combination of extensive NMR spectroscopic analyses, HRESIMS data, and ECD calculation. Both janthinopolyenemycins A and B showed activity in inhibiting the growth of Candida albicans with a MIC value of 15.6 μg/mL and a MBC value of 31. 25 μg/mL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect