A restraint-free small animal SPECT imaging system with motion tracking
| Autor: | Andrew G. Weisenberger, Shaun S. Gleason, Brian Kross, James S. Goddard, Vladimir Popov, R. Wojcik, Michael J. Paulus, B. Welch, Mark F. Smith, S. Majewski, Martin G. Pomper, Steven R. Meikle |
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| Rok vydání: | 2005 |
| Předmět: |
Physics
Nuclear and High Energy Physics Photomultiplier medicine.medical_specialty medicine.diagnostic_test business.industry Tracking system Iterative reconstruction Single-photon emission computed tomography law.invention Optics Nuclear Energy and Engineering Match moving law Spect imaging medicine Medical physics Electrical and Electronic Engineering business Image resolution Gamma camera |
| Zdroj: | IEEE Transactions on Nuclear Science. 52:638-644 |
| ISSN: | 0018-9499 |
| Popis: | We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction. |
| Databáze: | OpenAIRE |
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