Objective: Antifungal activity of total ethanolic extract and fractions of Usnea varieties were proved against Aspergillus niger, Penicillium digitatum, and Rhizopus nigricans fungi. Methods: To perform the study of relative antifungal activity (AFR), flu

Autor:	Oscar Eduardo Rodríguez Aguirre, Luis Miguel Pombo Ospina, Dayanna Cabra Gacha, Janeth Arias Palacios
Rok vydání:	2020
Předmět:	Pharmacology Antifungal Penicillium digitatum Usnea Traditional medicine biology medicine.drug_class Aspergillus niger medicine Pharmaceutical Science Rhizopus nigricans Pharmacology (medical) biology.organism_classification
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :171-174
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2020.v13i10.38962
Popis:	Objective: Antifungal activity of total ethanolic extract and fractions of Usnea varieties were proved against Aspergillus niger, Penicillium digitatum, and Rhizopus nigricans fungi. Methods: To perform the study of relative antifungal activity (AFR), fluconazole and ketoconazole were used as standards. The inhibition coefficient 50 (IC50) for each extract and the fractions was determined. Results: It was established that the highest activity was presented by the acetone fraction with a value of 58.53. In the study of antifungal activity, the fraction that presented the best activity against P. digitatum was ethanolic with a value of 44.33, while for R. nigricans was petrol extract, with a value of 75.35 and finally for A. niger was the total extract with a value of 35.48. Conclusions: Comparing the values obtained from the extract and the different fractions resulted in the dichloromethane fraction showing the best values.
Databáze:	OpenAIRE
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