Short-Term Effects on Bone Turnover Markers of a Single High Dose of Oral Vitamin D3
| Autor: | Silvano Adami, Davide Gatti, Maurizio Rossini, Silvia Zanoni, Elena Fracassi, Luca Idolazzi, Ombretta Viapiana |
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| Rok vydání: | 2012 |
| Předmět: |
Vitamin
medicine.medical_specialty biology business.industry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry vitamin D deficiency Bone remodeling chemistry.chemical_compound Endocrinology Bolus (medicine) chemistry Internal medicine medicine Vitamin D and neurology Osteocalcin biology.protein Alkaline phosphatase business Type I collagen |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 97:E622-E626 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context: Vitamin D deficiency is often treated or prevented by high intermittent doses of vitamin D to achieve a better treatment adherence, but treatment outcomes were contradictory, and even a transient increase in fracture and fall risk was reported. Objective: The objective of the study was to investigate the short-term effects on bone turnover markers of a single bolus of vitamin D3. Design, Setting, Patients, and Intervention: Twelve elderly subjects (eight women, four men; mean age 76 ± 3 yr) were given a single oral bolus of 600,000 IU vitamin D3. Blood samples were taken at baseline and 1, 3, 7, 14, 30, 60, and 90 d after vitamin D3 administration. Twenty-four subjects served as controls. Main Outcome Measures: Changes in serum levels of 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D, PTH, C-terminal-telopeptides of type I collagen, cross-linked N-telopeptide of type I collagen (sNTX), osteocalcin, and bone-specific alkaline phosphatase. Results: No relevant changes in 25OHD and bone turnov... |
| Databáze: | OpenAIRE |
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