Effects of Long-Term Administration of Isradipine on Renal Hemodynamics and Sodium Metabolism

Autor:	da Silva A, Emilio Antonio Francischetti, Fagundes Vg, Barroso I
Rok vydání:	1992
Předmět:	Pharmacology Mean arterial pressure medicine.medical_specialty Isradipine business.industry Sodium Urology Renal function chemistry.chemical_element Washout Effective renal plasma flow Placebo chemistry Anesthesia Medicine Cardiology and Cardiovascular Medicine business Morning medicine.drug
Zdroj:	Journal of Cardiovascular Pharmacology. 19:90-92
ISSN:	0160-2446
DOI:	10.1097/00005344-199200001-00022
Popis:	The objective of this double-blind, placebo-controlled study was to evaluate the effects of isradipine on renal hemodynamics and function. Ten patients with mild-to-moderate hypertension were given isradipine at 2.5 mg twice daily for 3 months after 4 weeks of placebo washout. Renal studies were performed 2 h after the morning administration treatment. The results of these evaluations indicate that isradipine as monotherapy significantly reduced the mean arterial pressure, while the effective renal plasma flow was increased (+16%) and glomerular filtration rate remained virtually unchanged (−8.7 ml/min)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c7ddec91ade34df6ac1706fbff1dbe1 https://doi.org/10.1097/00005344-199200001-00022 Zobrazit plný text záznamu