LIPIODOL reduces the lytic activity of detergent sclerosants in vitro
| Autor: | Joseph Grace, David E. Connor, Lourens Bester, Kurosh Parsi, Christopher Rogan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
General Medicine 030204 cardiovascular system & hematology Pharmacology In vitro 030218 nuclear medicine & medical imaging Polidocanol 03 medical and health sciences 0302 clinical medicine Lytic cycle Sodium tetradecyl sulphate Lipiodol medicine Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Phlebology: The Journal of Venous Disease. 36:771-778 |
| ISSN: | 1758-1125 0268-3555 |
| Popis: | Objectives Contrast agents are used widely in the interventional setting and in particularly in the management of vascular anomalies and have also been used in combination with sclero-embolic agents. There is limited information on the interaction of contrast agents with sclerosant agents when used as mixtures. The aim of this study was to determine the effect of mixing radiological contrast agents with detergent sclerosants and measuring the effect on change in lytic activity of detergent sclerosants in vitro and by proxy the change in potency. Methods Red blood cell lysis was assessed following the incubation of two commonly used contrast agents, LIPIODOL® and ULTRAVIST®, mixed with detergent sclerosants, FIBROVEIN®, sodium tetradecyl sulfate (STS), and AETHOXYSKLEROL®, polidocanol (POL). Results The density of both contrast agents was higher than STS and POL and neither of the detergent sclerosants were miscible in LIPIODOL. LIPIODOL on its own caused cell lysis (1.01%, p Conclusions LIPIODOL, when mixed with sclerosant detergents (ratio 1:1) causes a reduction in the lytic activity of sclerosants and this effect was statistically significant and most prominent in lower sclerosant concentration mixtures. |
| Databáze: | OpenAIRE |
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