ChemInform Abstract: CrCl2 Mediated Addition of Allylic Halides or Phosphates to N- Protected α-Amino Aldehydes. Stereocontrolled Synthesis of a New Core for C2 Symmetric HIV-Protease Inhibitors

Autor:	Massimo Falorni, Maurizio Taddei, Paola Ciapetti
Rok vydání:	2010
Předmět:	Chromium Addition reaction Allylic rearrangement chemistry Stereochemistry Reagent Halide chemistry.chemical_element HIV Protease Inhibitor Stereoselectivity General Medicine
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199638054
Popis:	The addition of γ-monosubstituted allylchromium(III) reagents to N-protected α-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the group bonded to the nitrogen. The chromium(III) reagent derived from 3-chloromethyl-2-trimethylsilyl-1-propene was used to prepare a C2 symmetric HIV-protease inhibitor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c72a1d95e74c5385160c894b4958533 https://doi.org/10.1002/chin.199638054 Zobrazit plný text záznamu Plný text