Serum Copper Concentration as an Index of Lung Injury in Rats Exposed to Hemithorax Irradiation
| Autor: | Agostino Molteni, Joann M. Hinz, William F. Ward, E. J. Fitzsimons |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Radiation Lung medicine.diagnostic_test business.industry Penicillamine Biophysics Dose fractionation Lung injury Hydroxyproline chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Serum iron Radiology Nuclear Medicine and imaging Respiratory system Nuclear medicine business medicine.drug Dose Modification |
| Zdroj: | Radiation Research. 114:613 |
| ISSN: | 0033-7587 |
| DOI: | 10.2307/3577131 |
| Popis: | Serum copper concentration was evaluated as an index of lung injury (monitored by lung prostacyclin production) with respect to the effects of time, dose, dose fractionation, and penicillamine dose modification in rats irradiated to the right hemithorax. Both lung PGI2 production and serum Cu concentration increased with increasing /sup 60/Co gamma-ray dose in animals sacrificed 2 or 6 months postirradiation, and the highest values for both responses were observed at the latter autopsy time. At 2 months postirradiation, the elevations in lung PGI2 production and serum Cu concentration also were spared similarly when total radiation doses were delivered in five equal daily fractions as compared to single doses. Finally, the ability of D-penicillamine to ameliorate the radiation-induced hyperproduction of PGI2 by rat lung was accompanied by an attenuation of the dose-dependent increase in serum Cu concentration at 2 months postirradiation in the drug-treated rats. In contrast, serum iron concentration was independent of time, dose, and penicillamine. At 2 months after irradiation, there also was a dose-dependent increase in lung hydroxyproline (collagen) content, the magnitude of which correlated closely with serum copper concentration in individual animals. Thus serum copper concentration is an accurate and minimally invasive index of lung injury inmore » rats irradiated to the hemithorax and can predict lung hydroxyproline (collagen) content in individual irradiated rats.« less |
| Databáze: | OpenAIRE |
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