Serological Study of Otitis Media with ANCA Associated Vasculitis (OMAAV)
| Autor: | Masashi Suzuki, Kaori Tateyama, Kan Kishibe, Nozomi Nomi, Satoru Kodama, Yasuaki Harabuchi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Indirect immunofluorescence medicine.diagnostic_test business.industry IIf ANCA-Associated Vasculitis Physical examination urologic and male genital diseases Gastroenterology EIA method respiratory tract diseases Serology Otitis Otorhinolaryngology immune system diseases Internal medicine Immunology medicine cardiovascular diseases medicine.symptom skin and connective tissue diseases business Combined method |
| Zdroj: | Nippon Jibiinkoka Gakkai Kaiho. 118:1133-1142 |
| ISSN: | 1883-0854 0030-6622 |
| Popis: | Otitis media related with ANCA associated vasculitis is an intractable condition conditions that is resistant to conventional conservative treatment or surgical treatments. The name "otitis media with ANCA associated vasculitis (OMAAV)" has been proposed as a new concept for this disease. In the present study, we examined the clinical feature of 14 cases of OMAAV. We also investigated the usefulness of combined tests for ANCA detection. There were 11 females and 3 males, with a median age of 68.5 years. PR3-ANCA was positively detected in 4 (28.6%) patients, MPO-ANCA was detected in 6 (42.9%), and 4 (28.6%) were both ANCAs negative. During the course 6 patients developed pachymeningitis and 5 patients developed facial palsy. Plasma samples from 14 OMAAV patients were tested for the presence of ANCAs with five detection methods (3 PR 3-ANCA kits (direct ELISA, capture ELISA, anchor ELISA), 2 MPO-ANCA kits (direct ELISA, capture ELISA)) and the indirect immunofluorescence (II) technique. Six patients (42.9%) were positive for ANCA in clinical examination (single EIA method), while ANCA was positively detected in 9 patients (64.3%) with combined methods. In ANCA negative cases, ANCA should also be tested with a different technique such as new generation ELISA and IIF. |
| Databáze: | OpenAIRE |
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