Autor:	M. V. Astapova, S. M. Dranitsyna, E. A. Surina, Kostanian Ia, Valery M. Lipkin
Rok vydání:	2002
Předmět:	Nuclease biology medicine.medical_treatment Organic Chemistry medicine.disease Biochemistry Molecular biology law.invention chemistry.chemical_compound Interleukin 10 Leukemia Cytokine chemistry Apoptosis law medicine biology.protein Recombinant DNA DNA Promyelocyte
Zdroj:	Russian Journal of Bioorganic Chemistry. 28:74-76
ISSN:	1068-1620
DOI:	10.1023/a:1013914505515
Popis:	The nuclease activity of human interleukin-10, an immunosuppressive cytokine, was predicted on the basis of structural homology between the 97–105 sequence of human interleukin-10 and the DNA/RNA-hydrolyzing fragment of the endogenous differentiation factor for the HL-60 line of human promyelocyte leukemia cells. The human recombinant interleukin-10 was shown to cleave all forms of plasmid DNA. The role of interleukin-10 in the apoptosis induction in monocytic cells was hypothesized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c6dec5745e07fc685015c3ab865f834 https://doi.org/10.1023/a:1013914505515 Zobrazit plný text záznamu Full text from SpringerLink