8-O-β-D-Glucopyranosyl-2-methylchromone, a new chromone glycoside from the Tibetan medicine plant of Swertia punicea Hemsl
| Autor: | Lin-Yun Mou, Jian-Long Li, Gan-Peng Li, Hai-Yan Wu, Li-Jiao Hu, Min Wei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Glycoside Plant Science Tibetan medicine biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Nitric oxide HeLa 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Swertia punicea Cell culture Chromone Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Natural Product Research. 36:237-245 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2020.1777123 |
| Popis: | A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ESI-MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the literature. In vitro test, all compounds were evaluated for their anti-inflammatory activity through the determination of nitric oxide production. Compounds 1-2 were evaluated for cytotoxic activities against three human cancer cell lines (HeLa, MDA-MB-231 and A375) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. Furthermore, the chemotaxonomic significance of these compounds has also been described. |
| Databáze: | OpenAIRE |
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