A specific two-pulse release of rivastigmine using a modified time-controlled delivery system: A proof of concept case study

Autor: Adel Penhasi, Mila Gomberg
Rok vydání: 2018
Předmět:
Zdroj: Journal of Drug Delivery Science and Technology. 47:404-410
ISSN: 1773-2247
DOI: 10.1016/j.jddst.2018.08.009
Popis: Currently, the orally administrated rivastigmine is based on twice daily formulations which also demand a titration process in order to increase the tolerability of the drug. In the present study an attempt was made to design and prepare an innovative single unit, once daily, double pulse release formulation for oral administration of rivastigmine in order to increase patient compliance without causing tolerance development. The pulsatile system was prepared as a tablet-in-tablet using a compression-coating method. An in-vitro dissolution test was utilized to determine the release profile of the drug from this system. The results showed that the designed delivery system provided two consecutive pulses of rivastigmine with a time difference of 6.5 h between the peaks of the pulses. The outer tablet provided an immediate release which lasted up to 4 h. The inner tablet, on the other hand, which was a film coated tablet, presented a capability of time-controlled delivery which was manifested by a lag time of 3 h followed by a burst release. The lag time was dependent, to a considerable extent, on the film coating weight. Surprisingly, the compression-coating did not alter the release features of the inner tablet whatsoever.
Databáze: OpenAIRE
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