Culling of Activated CD4 T Cells during Typhoid Is Driven by Salmonella Virulence Genes

Autor:	Stephen J. McSorley, Minelva R. Nanton, Amanda M. Griffin, Aparna Srinivasan
Rok vydání:	2009
Předmět:	T cell Immunology Biology Natural killer T cell Virology Microbiology Interleukin 21 Immune system medicine.anatomical_structure Interleukin 12 medicine Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell
Zdroj:	The Journal of Immunology. 182:7838-7845
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.0900382
Popis:	Pathogen-specific CD4 T cells are activated within a few hours of oral Salmonella infection and are essential for protective immunity. However, CD4 T cells do not participate in bacterial clearance until several weeks after infection, suggesting that Salmonella can inhibit or evade CD4 T cells that are activated at early time points. Here, we describe the progressive culling of initially activated CD4 T cells in Salmonella-infected mice. Loss of activated CD4 T cells was independent of early instructional programming, T cell precursor frequency, and Ag availability. In contrast, apoptosis of Ag-specific CD4 T cells was actively induced by live bacteria in a process that required Salmonella pathogenicity island-2 and correlated with increased expression of PD-L1. These data demonstrate efficient culling of initially activated Ag-specific CD4 cells by a microbial pathogen and document a novel strategy for bacterial immune evasion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c59f884b67195e51c3a1e13cbfdfdb3 https://doi.org/10.4049/jimmunol.0900382 Zobrazit plný text záznamu