Solubility of 1-(3-Bromopropoxy)-4-Chlorobenzene in Aqueous Ethanol Mixtures From (273.15 to 303.15) K

Autor:	Ziyu Lei, Yonghong Hu, Xinmin Jiang, Wenge Yang, Rongrong Tang, Fei Shen
Rok vydání:	2013
Předmět:	Omoconazole Nitrate Biophysics Thermodynamics Monitoring system Aqueous ethanol Atmospheric temperature range Biochemistry law.invention chemistry.chemical_compound chemistry law Chlorobenzene Organic chemistry Physical and Theoretical Chemistry Crystallization Solubility Molecular Biology
Zdroj:	Journal of Solution Chemistry. 42:272-281
ISSN:	1572-8927 0095-9782
DOI:	10.1007/s10953-013-9962-4
Popis:	1-(3-Bromopropoxy)-4-chlorobenzene is an important intermediate for the manufacture of omoconazole nitrate. The solubilities of 1-(3-bromopropoxy)-4-chlorobenzene in aqueous ethanol solutions were measured within the temperature range of (273.15–303.15) K using a laser monitoring system. For the temperature range investigated, the solubilities of 1-(3-bromopropoxy)-4-chlorobenzene in the aqueous ethanol mixtures increase with increasing temperature. The solubility data were regressed by the Buchowski–Ksiazaczak λh and the modified Apelblat models. The modified Apelblat equation and the Buchowski–Ksiazaczak λh equation provided accurate mathematical representations of the experimental results. The calculated solubilities showed good agreement with the experimental data. The root-mean-square deviations of the modified Apelblat model were lower than those of the Buchowski–Ksiazaczak λh model. This study provided valuable data for the purification of 1-(3-bromopropoxy)-4-chlorobenzene by crystallization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c59c0f37b25d722fdbb76c9cdf3a23a https://doi.org/10.1007/s10953-013-9962-4 Zobrazit plný text záznamu Full text from SpringerLink