Fatty Acid Profile andin VitroBiological Activities ofAllophylus africanus(P. Beauv)
| Autor: | Zhiqiang Liu, I. A. Oladosu, Olaoye Solomon Balogun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Linolenic acid DPPH medicine.medical_treatment Vaccenic acid Biology Sapindaceae complex mixtures Palmitic acid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Botany medicine Food science Pharmacology chemistry.chemical_classification Fatty acid biology.organism_classification 030104 developmental biology Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis visual_art visual_art.visual_art_medium Bark |
| Zdroj: | Journal of Herbs, Spices & Medicinal Plants. 22:238-246 |
| ISSN: | 1540-3580 1049-6475 |
| DOI: | 10.1080/10496475.2016.1193587 |
| Popis: | GC-MS analysis of derivatized oily chromatographic fractions from leaf and root bark extracts of Allophylus africanus indicated palmitic (leaf, 30.87%; root bark, 25.23%), linolenic (leaf, 19.41%; root bark, 14.20%), and stearic (leaf,12.50%; root bark 19.07%) acids as major constituents; in addition, the oil from the root bark had vaccenic acid (15.93%). In vitro antioxidant, antidiabetic, and anticancer studies of the methanol extract and its partitioned fractions using DPPH, alpha-glucosidase, and human lung adenocarcinoma cells (A549) showed that the water-soluble fractions of the leaf, stem, and root extracts had higher antioxidant potential than the standard ascorbate. The crude and water fractions of stem and root bark inhibited α-glucosidase enzyme in a concentration-dependent manner, with higher activity than standard drug Acarbose at concentration greater than 50 μg.mL–1. However, none of the tested sample was as cytotoxic as 5-fluorouracil. |
| Databáze: | OpenAIRE |
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