Prognostic Impact of Triple Negative Phenotype in Conservatively Treated Breast Cancer
| Autor: | Viviana Barbieri, Domenico Genovesi, Pietro Sanpaolo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Chemotherapy Multivariate analysis Proportional hazards model business.industry medicine.medical_treatment medicine.disease Surgery Radiation therapy Breast cancer Internal medicine Internal Medicine medicine Adjuvant therapy Hormone therapy business Grading (tumors) |
| Zdroj: | The Breast Journal. 17:377-382 |
| ISSN: | 1075-122X |
| DOI: | 10.1111/j.1524-4741.2011.01100.x |
| Popis: | To evaluate overall survival (OS), disease-free survival (DFS), and local-recurrence free survival (LRFS) rates in a subgroup of patients affected by breast cancer expressing a particular phenotype (estrogen receptor negative, progesterone receptor negative, and Human Epidermal Growth Factor receptor 2 negative) known as “triple negative” (TN). Data of 387 women affected by early breast cancer who underwent whole-breast radiotherapy after conservative surgery with or without chemotherapy and/or hormone therapy between January 2002 and December 2008, in the Department of Radiotherapy at Regional Cancer Center, were retrospectively evaluated. Chi-squared test was used to compare prognostic factors (age, histology, tumor size, nodal status, grading, and adjuvant therapy) between TN patients and non-TN patients. OS, DFS, and LRFS rates were analyzed using Kaplan–Meier proportional log-rank test; impact of prognostic factors on poor outcome was evaluated using Cox regression stepwise method on univariate and multivariate analysis. Mean follow-up time was 57.6 months (range13.7–109.7). TN patients were more likely to have ≥T2 tumors (p = 0.0003), grade 3 tumors (p = 0.0001) and to receive chemotherapy as adjuvant therapy (p = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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