NEUROPROTECTIVE POTENTIAL OF AZADIRACHTA INDICA LEAVES IN DIABETIC RATS
| Autor: | Naveen Kumar Gupta, Veena Puri, Nidhi Srivastva, Sanjeev Puri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology business.industry Pharmaceutical Science Azadirachta Streptozotocin Pro-oxidant biology.organism_classification medicine.disease_cause medicine.disease Neuroprotection Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Hyperalgesia Medicine Pharmacology (medical) medicine.symptom business Oxidative stress medicine.drug |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. 10:243 |
| ISSN: | 2455-3891 0974-2441 |
| DOI: | 10.22159/ajpcr.2017.v10i4.16657 |
| Popis: | Objective: Azadirachta indica is a treasure of multiple pharmacological properties and presently leaves of this plant have been explored to evaluate the neuroprotective potential in diabetic rats. Methods: Male Sprague-Dawley rats were injected with single intra peritoneal dose of streptozotocin (60mg/ Kg body weight (BW.) to develop animal model of diabetes. Post twenty one days of streptozotocin induction, animals were treated with aqueous Azadirachta indica Leaf Extract (ALE, 600mg/Kg BW.) for seven consecutive days. Followed this, all animals were evaluated for the levels of blood glucose, lipid peroxidation (LPO), C Reactive Proteins (CRP), pro oxidant biomarkers and histological changes. Results: Streptozotocin treated rats exhibited elevated levels of blood glucose, LPO, CRP and altered pro oxidant biomarkers in comparison to control rats. Additionally, histological alterations/damage was evidenced as fragmentation, vacuolization, inflammation etc. However, ALE treatment to these rats significantly decreased blood glucose levels, LPO, CRP levels and restored pro-oxidants status. Light microscopic and ultra microscopic analysis also indicated less damage, tissue architectural changes in comparison to untreated diabetic rats. Further decrease in hyperalgesia and inflammation levels; along with protective and restorative changes following ALE treatment suggested the neuroprotective potential of Azadirachta indica leaves in diabetic rats. Conclusion: The oral administration of ALE to streptozotocin induced diabetic animals resulted in neuro-protection against degenerative oxidative stress associated with metabolic and histopathological damage in the brain. Key words: Azadirachta indica , Antioxidants, Hyperalgesia, Neuroprotection |
| Databáze: | OpenAIRE |
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