PkStaMp Library for Constructing Optimal Population Designs for PK/PD Studies

Autor:	Mindy Magee, Sergei Leonov, Valerii V. Fedorov, Alexander Aliev, Brian McHugh
Rok vydání:	2012
Předmět:	Statistics and Probability Optimal design education.field_of_study Optimal sampling business.industry Population Nonlinear system Software Modeling and Simulation Statistics Mixed effects business MATLAB education computer PK/PD models computer.programming_language Mathematics
Zdroj:	Communications in Statistics - Simulation and Computation. 41:717-729
ISSN:	1532-4141 0361-0918
DOI:	10.1080/03610918.2012.625273
Popis:	We discuss a Matlab-based library for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. The software relies on optimal design theory for nonlinear mixed effects models and, in particular, on the first-order optimization algorithm. The library includes a number of popular compartmental PK and combined PK/PD models and can be extended to include more models. An outline of inputs/outputs is provided, some algorithmic details and examples are presented, and future work is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1c28982f32d3afe77b95307b5b04ce97 https://doi.org/10.1080/03610918.2012.625273 Zobrazit plný text záznamu