Defibrotide for Sinusoidal Obstruction Syndrome and Nodular Regenerative Hyperplasia After Oxaliplatin-Based Hepatic Intra-Arterial Chemotherapy: A Case Report
| Autor: | Amaury Druet, Caroline Viala, Yann Touchefeu, Jean-François Mosnier, Tamara Matysiak-Budnik, Erwan Corbineau |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Colorectal cancer business.industry medicine.medical_treatment Gastroenterology Defibrotide medicine.disease Oxaliplatin Hepatic arterial infusion Oncology Internal medicine medicine bacteria Portal hypertension Complication business Nodular regenerative hyperplasia medicine.drug |
| Zdroj: | Clinical Colorectal Cancer. 21:e98-e101 |
| ISSN: | 1533-0028 |
| DOI: | 10.1016/j.clcc.2021.10.003 |
| Popis: | Clinical Practice Points • Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of oxaliplatin-based chemotherapy. • Nodular regenerative hyperplasia can be associated at a late stage of SOS, and should be suspected in case of signs of portal hypertension such as thrombocytopenia or splenomegaly. • To our knowledge, this is the first report of SOS occurring after oxaliplatin hepatic arterial infusion (HAI). • We report a case of a 43-year-old man, with colorectal liver metastases with SOS associated with nodular regenerative hyperplasia, diagnosed after 28 cycles of oxaliplatin-based HAI, treated with defibrotide but with a fatal outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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