| Autor: | Mirjam Czjzek, Anne Lecroisey, Muriel Delepierre, Nadia Izadi, Richard Haser, Pascal Arnoux, Cécile Wandersman |
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| Rok vydání: | 1999 |
| Předmět: |
0303 health sciences
Siderophore biology Pathogenic bacteria 010402 general chemistry medicine.disease_cause biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Microbiology Transport protein 03 medical and health sciences chemistry.chemical_compound chemistry Structural Biology Serratia marcescens Genetics medicine Secretion Hemoglobin Heme Bacteria 030304 developmental biology |
| Zdroj: | Nature Structural Biology. 6:516-520 |
| ISSN: | 1072-8368 |
| DOI: | 10.1038/9281 |
| Popis: | Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host's iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release. |
| Databáze: | OpenAIRE |
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