Abstract P493: Outcomes in Young Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy: A Multi-Centre Experience
| Autor: | Benjamin Tan, Michael Forsting, Staffan Holmin, Andreas Kastrup, Hanna Styczen, Fabian Arnberg, Sebastian Fischer, Lukas Meyer, Daniel Behme, Sebastian Mönch, Volker Maus, Nuran Abdullayev, Tommy Andersson, Jens Fiehler, Cunli Yang, Christian Maegerlein, Christoph Kabbasch, Ching-Hui Sia, Vanessa Chen, Aftab Ahmad, Carol Tham, Tian-Ming Tu, Ala Jamous, Panagiotis Papanagiotou, Tsong-Hai Lee, Vivek Sharma, Prakash R Paliwal, Chan-Lin Chu, Aloysius Tan, Anil Gopinathan, Leonard L.L. Yeo, Bernard P.L. Chan, Raymond C.S. Seet |
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| Rok vydání: | 2021 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty Standard of care business.industry medicine.medical_treatment Thrombolysis medicine.disease Internal medicine Occlusion Cardiology medicine Neurology (clinical) Young adult Multi centre Cardiology and Cardiovascular Medicine business Acute ischemic stroke Stroke Large vessel occlusion |
| Zdroj: | Stroke. 52 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Introduction: Endovascular thrombectomy(EVT) is considered standard of care for anterior circulation acute ischemic stroke(AIS) with large vessel occlusion(LVO). Young AIS-LVO patients have distinctly different underlying stroke mechanisms and etiologies. Methods: In this multicenter cohort study conducted from August 2014 to January 2020, we investigated the safety and effectiveness of EVT in young AIS-LVO patients aged≤50 years and evaluated associations between demographics, stroke etiology, neuroimaging factors and clinical outcomes, including functional outcomes, in-hospital mortality and symptomatic intracranial haemorrhage(sICH) in univariable and multivariable regression models. Results: 275 AIS-LVO patients from 10 tertiary centers in Germany, Sweden, Singapore and Taiwan were included. The more common TOAST subtypes included cardioembolism (82/275, 29.8%) and stroke of undetermined etiology (85/275, 30.9%). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%) and had the highest rate of good functional outcomes (29/42, 69.0%). Successful reperfusion was achieved in 85.1% (234/275). Excellent and good functional outcomes were achieved in 48.0% (132/275) and 66.0% (182/275) respectively. sICH occurred in 6.5% (18/275). National Institute of Health Stroke Scale (NIHSS) at presentation was inversely related with good functional outcomes (aOR0.92, 95% CI 0.88- 0.96 per point increase, p Conclusion: While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT. |
| Databáze: | OpenAIRE |
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