Crossreactive allergen-specific IgE in children with birch pollen allergic rhinitis

Autor:	S A Mazurina, P V Samoylikov, V B Gervazieva, P I Gushchin
Rok vydání:	2017
Předmět:	Allergy biology business.industry fungi General Medicine medicine.disease_cause Immunoglobulin E medicine.disease Birch pollen Allergen Oral allergy syndrome Correlation analysis Immunology medicine biology.protein Food allergens business Allergen specific IgE
Zdroj:	Russian Journal of Allergy. 14:66-70
ISSN:	2686-682X 1810-8830
DOI:	10.36691/rja325
Popis:	Objective. The aim of this study was to research a sIgE allergen profile of birch pollen and to evaluate a contribution of some homologous food allergens as well as latex allergen to the development of sensibility in allergic rhinitis (AR) / rhinoconjunctivitis patients, in focus of cross-reactivity and oral allergy syndrome.. Methods. Blood sera of 21 AR/rhinoconjunctivitis patients (at the age of 3 to 16) and 20 healthy persons without allergy symptoms were used. sIgE to birch pollen, soybean, latex, apple and celery as well as the total IgE levels were measured by the ImmunoCAP method (Phadia, Sweden) and the ELISA kits (Alkorbio, Russia). Results. We detected high total IgE levels, sIgE to allergens of birch pollen, apple, celery, as well as to recombinant allergens of birch Bet v 1, Bet v 2 and soybean - Gly m 4 in AR patients. Correlation analysis of IgE humoral response to homologous proteins showed the direct valid dependence between the sIgE levels to birch isoallergen Bet v 1 and soy isoallergen Gly m 4 (r=0,84; p
Databáze:	OpenAIRE
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