Relationship between dynamic changes in subpopulations of blood monocytes and the development of complications in patients with acute myocardial infarction
| Autor: | O. M. Parkhomenko, I. V. Tretyak, O. V. Dovhan, O. V. Shumakov, T. V. Talayeva |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Ukrainian Journal of Cardiology. 27:9-17 |
| ISSN: | 2664-4479 1608-635X |
| DOI: | 10.31928/1608-635x-2020.4.917 |
| Popis: | The aim – to determine the extent of different subpopulations of blood monocytes in acute myocardial infarction (AMI) with ST-segment elevation patients on day 1 and 7 and to evaluate the relationship between their content and the dynamics of changes and the risk of complications after AMI.Materials and methods. The composition of individual subpopulations of monocytes in the peripheral venous blood (and general clinical and biochemical blood tests) was evaluated in 50 pts with STEMI (who were admitted within 6 hours after the onset of the disease) at admission (before primary PCI) and on day 7. All patients received standard recommended therapy. Dynamic heart echocardiography was also performed on the 1st and 7th day. All patients were divided into 2 groups depending on the dynamical increase (1 group – 21 pts) or decrease (2 group – 29 pts) of classical monocytes (CD14hiCD16–) subpopulation during 7 days of follow-up. The control group included 15 healthy subjects with no signs of coronary heart disease and 23 pts with chronic coronary heart disease without AMI.Results and discussion. In subgroup 1, the percentage of the «classical» fraction of monocytes during the observation increased to 89.0±1.2 %, which was 4.2 % more than on the 1st day and 12.5 % more than in the control group (р |
| Databáze: | OpenAIRE |
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