| Popis: |
Ulva fasciata, U. lactuca, Amphiroa anceps, Corallina mediterranea, and Sargassum filipendula extract were screened for their in vitro anticancer activity against human breast adenocarcinoma cell line (MCF-7) and colorectal carcinoma cell line (HCT-116). Algal extracts exhibited significantly dose-dependent anticancer activity without significant cytotoxicity against normal human fibroblasts. The maximum inhibitory percentages against MCF-7 and HCT-116 cell lines were recorded by U. lactuca (88.5 ± 1.08 %) and A. anceps (86.1 ± 2.88 %) extracts. Algal extracts showed cytotoxic effect against MCF-7 cell line with fifty percent inhibitory concentration (IC50) values ranging from 3.54 ± 1.2 to 21.2 ± 1.1 µg mL-1. The seaweeds extract has a less cytotoxic effect against HCT-116. FTIR and GC-MS analyses of the extracts indicated that the anticancer potential of the tested seaweeds may be returned to the presence of various anticancer compounds such as palmitic acid, oleic acid, retinoic acid, dihydroactinidiolide, thiosemicarbazide, diisobutyl phthalate, and phytol. Thus, seaweed extracts may be a promising natural source of safe anticancer agents against human breast and colon cancers. |
