Nickel(0)-catalyzed Coupling Reactions of Carbonyls and Alkenes with Reducing Reagents Giving Six- and Seven-membered Benzocycloalkanols
| Autor: | Yukari Hayashi, Ravindra Kumar, Masato Ohashi, Sensuke Ogoshi, Yoichi Hoshimoto |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Triethylborane chemistry.chemical_element General Chemistry Reaction intermediate 010402 general chemistry 01 natural sciences Medicinal chemistry Coupling reaction 0104 chemical sciences Catalysis Nickel chemistry.chemical_compound Reagent Organic chemistry Nickel catalyst Triethylsilane |
| Zdroj: | Chemistry Letters. 46:1096-1098 |
| ISSN: | 1348-0715 0366-7022 |
| DOI: | 10.1246/cl.170394 |
| Popis: | Nickel(0)-catalyzed coupling reactions of 1,6- and 1,7-enals with triethylsilane have been utilized to synthesize six- and seven-membered silyl-protected benzocycloalkanols. When triethylborane was employed as the reducing reagent, tetralol derivatives were obtained. Results of deuterium-labeling experiments suggest the formation of oxanickelacycles as a key reaction intermediate. |
| Databáze: | OpenAIRE |
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